Not to be confused with Divine-Alien Physiology. The Journal of Pediatrics is an international peer-reviewed journal that advances pediatric research and serves as a practical guide for pediatricians who manage health and diagnose and treat disorders in infants, children, and adolescents.The Journal publishes original work based on standards of excellence and expert review. chan tracy. If the 0 and 1 of binary systems can be considered a duality, a transdual characters fundamental existence might be definable as being in [131], Others propose an oligodendrocyte stress as primary dysfunction, which activates microglia creating the NAWM areas[132] and others propose a yet-unknown intrinsic CNS trigger induces the microglial activation and clustering, which they point out could be again axonal injury or oligodendrocyte stress. While most of them are still under research, there are some of them already well stablished: Meningeal tertiary lymphoid-like structures, F. Quintana et al., Specific Serum Antibody Patterns Detected with Antigen Arrays Are Associated to the Development of MS in Pediatric Patients, Neurology, 2012. Some modes require energy to maintain form. Max Mercury, Jay Garrick, and Jesse Quick all attempted to assist Wally by distracting the Black Flash; Wally finally defeated the Black Flash by racing it to the end of time, to a point where Death would have no meaning, causing it to dissipate. [13] GM atrophy is independent of classical MS lesions and is associated with physical disability, fatigue, and cognitive impairment in MS[14], At least five characteristics are present in CNS tissues of MS patients: Inflammation beyond classical white matter lesions, intrathecal Ig production with oligoclonal bands, an environment fostering immune cell persistence, and a disruption of the bloodbrain barrier outside of active lesions. Variation of Cosmic Entity Physiology. The latter hypothesis is further corroborated by a recent study that demonstrated significant differences in routine cerebrospinal fluid findings between patients with pattern I lesions and patients with non-pattern I lesions, including a lack of CSF-restricted oligoclonal bands, in most pattern II and III patients. Link Between Gut Flora and Multiple Sclerosis Discovered. As it stands, Type 1 corresponds to being beyond certain kinds of dual systems, but not all duality. Some modes may become corrupt and may have to be given up or fixed. In order to pass through, molecules must be taken in by transport proteins or an alteration in the BBB permeability must occur, such as interactions with associated adaptor proteins like ZO-1, ZO-2 and ZO-3. WebCarbon dioxide (chemical formula CO 2) is a chemical compound made up of molecules that each have one carbon atom covalently double bonded to two oxygen atoms. It has been found recently that B-cells are also involved. [58], After barrier breakdown symptoms may appear, such as swelling. WebThe ability to obtain powers in different forms and switch between powers and fighting technique. [133], Finally, other authors point to a cortical pathology which starts in the brain external layer (pial surface) and progresses extending into the brain inner layers[134]. [15] The scars that give the name to the condition are produced by astrocytes healing old lesions. This was already indicated by previous studies that found a relatively high rate of false diagnoses of MS among patients with AQP4-IgG-positive neuromyelitis optica spectrum disorders or MOG encephalomyelitis. [2] The gold standard for MS diagnosis is pathological correlation, though given its limited availability, other diagnosis methods are normally used. Barry Allen later became the new Black Flash after the old one was found "apparently dead". Combination of Evolution and Super Form. Peferoen, L., D. Vogel, Marjolein Breur, Wouter Gerritsen, C. Dijkstra, and S. Amor. This contrasts them with Abrahamic depictions of angels, who are agents of Heaven and are in opposition to the forces of Hell, but consistent with depictions of demons. Form Change/Swapping/Switching [2] Soon after, the title was taken by Professor Zoom in his corpse Black Lantern form. [65] Several possible biochemical disrupters were proposed. WebGod Physiology: The Presence is a divine entity of infinite power. [66] Breakdown is responsible for monocyte infiltration and inflammation in the brain. It later returned to try and take Wally again, freezing time except for those who possessed a connection to the Speed Force. WebUganda, through Uganda National Bureau of Standards (UNBS) has been re-appointed Coordinator for the Food and Agriculture Organisation of the United Nations / World Health Organisation (FAO/WHO) Coordinating Committee for - DEATH BATTLE!-2. Variation of Cosmic Entity Physiology. This marks the beginning of an autoimmune attack which destroys myelin in active lesions. Research shows that views of nature have an impact on our psychology and physiology. BBB infection: It has also been pointed out that some infectious agents with positive correlation to MS, specially. -Google(Wikipedia, Web Sites) -Youtube(Blogs, Videos) Special Thanks to : All of Super Fanon which gave me inspiration to create this kind of Power. Claws: His hands contains clawed, that he can use for stabbing and slashing in combat. Inducing the formation of tight junctions can restore BBB integrity and reduces its permeability, which can be used to reduce the damage caused by lymphocyte and monocyte migration across the barrier as restored integrity would restrict their movement. [10] These lesions form in NAWM before bloodbrain barrier breakdown. Fertility and Sterility is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. AJOG's Editors have active research programs and, on occasion, publish work in the Journal. For some reason, the Maykrs choose to wear human-like facial masks that conceal their otherwise rather alien features. J. William Brown et al. The Maykr species is believed to be ancient, and they generally consider themselves to be gods and far beyond the lives of other species, whom they refer to only as 'mortals.' Prop 30 is supported by a coalition including CalFire Firefighters, the American Lung Association, environmental organizations, electrical workers and businesses that want to improve Californias air quality by fighting and preventing wildfires and reducing air pollution from vehicles. Pathophysiology is a convergence of pathology with physiology. Switch into different powers and abilities. Pathologist, Mechanical flow: Later the focus moved to softer hemodynamic abnormalities, which were showing precede changes in sub-cortical gray matter. In particular, some PPMS patients having a special clinical course named rapidly progressive multiple sclerosis could have a special genetic cause[47] and a different development process. If the 0 and 1 of binary systems can be considered a duality, a transdual characters fundamental existence might be definable as being in-between the numbers of 0 and 1, being 0 and 1 at once, being defined as being a 2, or as not being describable through any numbers at all at the higher levels. [45] It seems that neurodegeneration is produced by damaged mitochondria, which in turn comes from activated microglia.[46]. WebThe Maykrs are an advanced extra-dimensional race that hail from the realm of Urdak. [44], In multiple sclerosis, inflammation, demyelination, and neurodegeneration are observed together. The Maykrs show little to no remorse regarding the billions of lives that are lost in the process of sustaining their civilization, and will stop at nothing to enable the complete consumption of entire planets for their own good. NeuroscienceNews. MS could be considered a heterogeneous condition or a new medical entity will be defined for these cases. It came for Wally West to draw him back to the Speed Force, but instead took Linda Park, Wally's girlfriend, into the Speed Force. Ron Wagner In the air, carbon dioxide is transparent to visible light but absorbs infrared radiation, acting as a greenhouse gas.It is a trace gas in Earth's Dr. Samuel Haydenhave described the Maykrs as a dying race, and it's possible that they cannot reproduce at all, being completely dependent on Argent Energy in order to prolong the lifespans of already living Maykrs, or most especially from succumbing to Transfiguration. Instead of intracranial venous problems he described extracranial blockages, and he stated that the location of those obstructions seemed to influence the clinical course of the disease. [86] Historically, several theories about how these areas appear have been presented: The search for an auto-antigen has taken a long time, but at least there is one reported. The underlying cause is currently unknown. They have used this technological superiority to subjugate and essentially vassalize 'lesser' civilizations, posing as their gods and offering technological enlightenment and the questionably accurate 'life after death' in return for other species' servitude. Related to Multiple Forms. Several types of damage appear in the brain: normal appearing white matter (NAWM) and characteristic lesions. It is possible the Maykrs wear these as a social adornment due to their long history with the people ofArgent D'Nur, since the narrow facial features and somewhat angled eye placement resemble theirs. The Maykrs are also extremely arrogant and, due to their technological superiority or Argent-induced immortality, theygenerally view themselves as gods. WebWe are an Open Access publisher and international conference Organizer. This theory in part could also explain why some patients report amelioration under dietary treatment. Though autoimmune demyelination is strong, axons are preserved, showing that the standard model of a primary demyelination cannot be hold. The duality of fire would be fire and not fire. WebMultiple sclerosis is an inflammatory demyelinating disease of the CNS in which activated immune cells invade the central nervous system and cause inflammation, neurodegeneration, and tissue damage.The underlying cause is currently unknown. WebOnline analytical processing, or OLAP (/ o l p /), is an approach to answer multi-dimensional analytical (MDA) queries swiftly in computing. There are no records of how the Father came to the Maykrs or if he had any physical form before the Maykrs. WebGrail is the daughter of Darkseid, prophesied to cause great destruction at the behest of the Anti-God. [90] Supporting this study, a monoclonal antibody against the viral capside (Temelimab) has shown good results in trials in phase IIb. These are called Normal Appearing White Matter (NAWM) and Normal Appearing Grey Matter (NAGM). What remains of the Maykrs fell to the corruption of Hell and turning into demons. [68], Using iron nanoparticles, involvement of macrophages in BBB breakdown can be detected. WebTransduality is the state of being wherein an entity exists independently of, and qualitatively beyond, various dual systems, ranging from very specific, limited sets of dual distinctions to duality itself on a conceptual level. Some modes may need different transformers to switch any forms. The power to be an entity beyond all dimensionality. WebA abstract data type (ADT) A mathematical model for data types in which a data type is defined by its behavior (semantics) from the point of view of a user of the data, specifically in terms of possible values, possible operations on data of this type, and the behavior of these operations. Changes in NAWM include axonal injury without demyelination, low-grade inflammation, and microglial and astrocytic activation[48], MS lesions develop inside NAWM areas. VS Battles Wiki is a FANDOM Anime Community. If the existence of any of these subsets of MS is confirmed, the situation would be similar to what happened for Devic Disease and Aquaporin-4[citation needed]. Current models can be divided into two categories: inside-out and outside-in. Connecting to nature in this way allows us to draw on geometric design patterns for inspiration. That is to say, that the duality in question can be decribed as "A" and "not A" where A is some object or attribute. Thank you Buddies you are best :). The Khan Maykr without her facial mask, revealing her much more alien face, possibly corrupted by long-term consumption of Argent Energy. DC Database is a FANDOM Comics Community. Currently it is unknown what the primary cause of MS is; if MS is a heterogeneous disease, the lesion development process would not be unique. S164-S164. WebEssentials of Anatomy And Physiology. In the former, it is hypothesized that a problem in CNS cells produces an immune response that destroys myelin and subsequently breaks the BBB. See Also: Multiform Balance and Stance System. In that case, the mask would possibly make the Argenta more inclined to believe the Maykrs are gods, rather than aliens. Due to experimentation by Team Rocket, Vee (Pokmon Adventures) could freely shift between its first three evolutions. Lucifer, for example, is described as being consumed with pride, and even to have the ability to appear as an "angel of light," and it is consistent with the Maykrs' sense of entitlement to rule other intelligent species and treat them like animals to be consumed. Monkey D. Luffy (One Piece) changing into Gear 3. They are much different than merely zero-dimensional creatures; as rather than simply lacking dimensions at all (and thus are geometrically infinitesimal in every possible direction), they are conceptually superior to the concepts of dimensional physics. WebBrowse our listings to find jobs in Germany for expats, including jobs for English speakers or those in your native language. The Maykrs are an advanced extra-dimensional race that hail from the realm of Urdak. Smooth muscle lacks the striations characteristic of cardiac and This contrasts with data structures, which are concrete representations of The Khan Maykr has a lifespan of around 10,000 Earth-years, and once the Khan Maykr dies a new one will be formed through an unknown process believed to involve the fusing of several lesser Maykrs. The Stranger is a cosmic entity that typically shows up alongside heavy hitters like Eternity, Galactus, Lord Chaos, and Master Order when major events are occurring in the universe. Some hypotheses about how the BBB is compromised revolve around the presence of compounds in the blood that could interact with vessels only in the NAWM areas. Users of this ability are able to obtain certain powers in different forms or modes that allow them to create new abilities and control certain powers. The Black Flash fulfills the role of Death for those who possess super-speed, returning them to the source of their powers: the Speed Force. There are three clinical phenotypes: relapsing-remitting MS (RRMS), characterized by periods of neurological worsening following by remissions; secondary-progressive MS (SPMS), in which there is gradual progression of neurological dysfunction with fewer or no relapses; and primary-progressive MS (MS), in which neurological deterioration is observed from onset. [12], The evolution of a preactive lesion is related to microglia reactivity. [61] MS has an important vascular component. ", "Relapsing and Remitting Multiple Sclerosis: Pathology of the Newly Forming Lesion", "Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways", "Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis", "Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis", "Mitochondrial defects in acute multiple sclerosis lesions", 10.1002/1531-8249(199909)46:3<296::AID-ANA4>3.0.CO;2-#, "Nuclear Receptor NR1H3 in Familial Multiple Sclerosis", "Primary Progressive Multiple Sclerosis: Putting Together the Puzzle", "Three-Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis", "Inside-Out versus Outside-In models for virus induced demyelination: axonal damage triggering demyelination", "Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis", "The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis: a serial diffusion MRI study", "Identification of an essential endogenous regulator of bloodbrain barrier integrity, and its pathological and therapeutic implications", "Elevated matrix metalloproteinase-9 and degradation of perineuronal nets in cerebrocortical multiple sclerosis plaques", "Population-Wide Principal Component-Based Quantification of Blood-Brain-Barrier Dynamics in Multiple Sclerosis", "Permeation of blood-borne IL15 across the bloodbrain barrier and the effect of LPS", "Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier", "Monocyte migration and LFA-1 mediated attachment to brain microvascular endothelia is regulated by SDF-1 through Lyn kinase", "Magnetic resonance imaging of human brain macrophage infiltration", "Biomarkers indicative of bloodbrain barrier disruption in multiple sclerosis", "Adhesion molecules in multiple sclerosis: relation to subtypes of disease and methylprednisolone therapy", New Therapeutic Target For Treatment Of Multiple Sclerosis, Jan. 2008, "Pathological Expression of CXCL12 at the Blood-Brain Barrier Correlates with Severity of Multiple Sclerosis", "Imaging correlates of leukocyte accumulation and CXCR4/CXCR12 in multiple sclerosis", "Impact of methylprednisolone treatment on the expression of macrophage inflammatory protein 3alpha and B lymphocyte chemoattractant in serum of multiple sclerosis patients", "The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity", "The bloodbrain barrier in cortical multiple sclerosis lesions", "White Matter Hemodynamic Abnormalities precede Sub-cortical Gray Matter Changes in Multiple Sclerosis", University of Zurich(2018, October 11). Variation of Archetype Empowerment. Dante (Devil May Cry series) can switch between four different Styles in combat: Deoxys (Pokmon) possesses four different forms that he can utilize and transform into; from left to right, Attack, Normal, Defense, and Speed. The Journal In any case, understanding lesion patterns can provide information about differences in disease between individuals and enable doctors to make more effective treatment decisions. Associations. Several theories have been proposed to explain it. [130] The theory of the trans-synaptic degeneration, is compatible with other models based in the CSF biochemistry. Typical applications of OLAP include business reporting for [1][2], The Maykrs are an incredibly advanced civilization, with technological abilities far beyond both the people ofEarthandArgent D'Nur. In GLIA, vol. [50] When the attack is resolved, a characteristic glial scar is formed by astrocytes. [74] Another protein involved is CXCL12,[75] which is found also in brain biopsies of inflammatory elements,[76] and which could be related to the behavior of CXCL13 under methylprednisolone therapy. Related to Multiple Forms. To summarize: Beyond-Dimensional Physiology is beyond the concept of all dimensionalities. [57], The BBB is compromised due to active recruitment of lymphocytes and monocytes and their migration across the barrier. Connect, collaborate and discover scientific publications, jobs and conferences. Advanced version of Pan-Dimensional Physiology. A list of these boxes is presented here for your convenience. For instance, all organisms are made up of cells that process hereditary information encoded in genes, which can be transmitted to future generations.Another major theme is evolution, which explains [124] Whatever the problem is, it produces apoptosis of neurons respecting astrocytes[125], In 2012 it was reported that a subset of MS patients have a seropositive anti-Kir4.1 status,[126] which can represent up to a 47% of the MS cases, and the study has been reproduced by at least two other groups. [69] A special role is played by Matrix metalloproteinases. We have moved to a new external forum hosted at https://vsbattles.com. -Google(Wikipedia, Web Sites) -Youtube(Blogs, Videos) Special Thanks to : All of Super Fanon which gave me inspiration to create this kind of Power. However, the awakening of the Icon of Sin became the Maykrs' own undoing. Ilana Katz Sand et al. Be an entity beyond the concept of dimensionality. Thank you Buddies you are best :). [citation needed], According to one of the researchers involved in the original research, "Two patterns (I and II) showed close similarities to T-cell-mediated or T-cell plus antibody-mediated autoimmune encephalomyelitis, respectively. The duality of existence would be existence and not existence, which could equivalently be formulated as existence and nonexistence or existence and void. The Doom Slayer's disruption of the invasion forced the Khan Maykr to awaken the Icon of Sin to continue consuming the human race. This event incapacitated the Maykrs from creating a new Khan Maykr. Sub-power of Mode Manipulation. Maybe the strongest argument supporting this theory comes from the comparison with NMO. Also B-cells and microglia could be involved. At the same time as the birth of Diana to Hippolyta, the Amazonian assassin Myrina gave birth to the daughter of Darkseid in secret, aided by Penelope and watched by the oracle Menalippe. Multiple sclerosis can be pathologically defined as the presence of distributed glial scars (or sclerosis) in the central nervous system disseminated in time (DIT) and space (DIS). Quotations by or about Black Flash (New Earth), 15 Appearances of Black Flash (New Earth), 10 Images featuring Black Flash (New Earth), Character Gallery: Black Flash (New Earth), It should not be confused with the other personifications of death in the DCU: The. OLAP is part of the broader category of business intelligence, which also encompasses relational databases, report writing and data mining. Release of chemokines allow for the activation of adhesion molecules on the lymphocytes and monocytes, resulting in an interaction with the endothelial cells of the BBB which then activate the expression of matrix metalloproteinases to degrade the barrier. [42] Finally, some previously diagnosed with pattern II MS were later found to have in fact MOG-IgG-related encephalomyelitis, suggesting that both the current clinicoradiological diagnostic criteria for MS and the histopathological criteria for MS may be insufficiently specific. CCSVI: The term "chronic cerebrospinal venous insufficiency" was coined in 2008 by Paolo Zamboni, who described it in patients with multiple sclerosis. Their skin is pinkish and their features seem to be reminiscent of manydemons, or at least this is true for theKhan Maykr. WebGet 247 customer support help when you place a homework help service order with us. Grail the Godkiller. Some authors propose a primary neurodegenerative factor. The cause why the normal appearing areas appear in the brain is unknown, but seems clear that they appear mainly in the ventricles and that they predict the course of the disease.[85]. Given that MS lesions begin inside the NAWM areas, these areas are expected to be produced by the same underlying condition that produces the lesions, and therefore the ultimate MS underlying condition, whatever it is. It is not clear whether the Black Flash exists because the speedsters are simply too fast for traditional Death to capture, or as some sort of bizarre side-effect to their connection to the Speed Force. [43], Another development in this area is the finding that some lesions present mitochondrial defects that could distinguish types of lesions. Then, it was an "empire" (i.e., a great power) long before it had an emperor. Sora (Kingdom Hearts) can assume special "Drive Forms" that specialize in physical strength, magic, or a balance between the two. They are a hive-mind race, lead by the Khan Maykr. The Maykrs are an exceptionally long-lived race, but they are not immortal. List of Supernatural Powers and Abilities. [60], Recently it has been found that BBB damage happens even in non-enhancing lesions. The Republic was not a nation-state in the modern sense, but a network of towns left to rule Sub-Zero VS Glacius (Mortal Kombat VS Killer Instinct) - DEATH BATTLE! Some modes may have a time limit and users may need training to extend time limit or gain full control. Pathology is the medical discipline that describes conditions typically observed during a disease state; whereas physiology is the biological discipline that describes processes or mechanisms operating within an organism. So, for example, fire and water are not a duality. Uric acid added in physiological concentrations (i.e. Recent research as of 2019 point to one of the HERV-W viruses (pHEV-W), and specifically one of the proteins of the viral capsid that has been found to activate microglia in vitro. Those who have a checking or savings account, but also use financial alternatives like check cashing services are considered underbanked. Superpower Wiki is a FANDOM Anime Community. The other patterns (III and IV) were highly suggestive of a primary oligodendrocyte dystrophy, reminiscent of virus- or toxin-induced demyelination rather than autoimmunity. It is the enzyme GDP-L-fucose synthase.[87][88]. Book review", "Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis", "Chronic cerebrospinal venous insufficiency and multiple sclerosis", "Intracranial venous haemodynamics in multiple sclerosis", "Embryological background of truncular venous malformation in the extracranial venous pathways as the cause of chronic cerebro spinal venous insufficiency", "Transfer of multiple sclerosis into severe combined immunodeficiency mice by mononuclear cells from cerebrospinal fluid of the patients", "Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics", "Potassium channel KIR4.1 as an immune target in multiple sclerosis", "Autoantibodies to Potassium Channel KIR4.1 in Multiple Sclerosis", "Imaging Surrogates of Disease Activity in Neuromyelitis Optica Allow Distinction from Multiple Sclerosis", "Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation", "A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging", "The intrathecal, polyspecific antiviral immune response in neurosarcoidosis, acute disseminated encephalomyelitis and autoimmune encephalitis compared to multiple sclerosis in a tertiary hospital cohort", "kFLC Index: a novel approach in early diagnosis of Multiple Sclerosis", Lesional demyelinations of the central nervous system, Experimental autoimmune encephalomyelitis, Leukoencephalopathy with vanishing white matter, Megalencephalic leukoencephalopathy with subcortical cysts, https://en.wikipedia.org/w/index.php?title=Pathophysiology_of_multiple_sclerosis&oldid=1125097228, Wikipedia articles needing factual verification from September 2010, Articles with unsourced statements from May 2022, Articles with unsourced statements from October 2021, Articles containing potentially dated statements from 2010, All articles containing potentially dated statements, Articles with unsourced statements from October 2017, Creative Commons Attribution-ShareAlike License 3.0. It was reportedly seen before the deaths of Barry Allen and Johnny Quick; Max Mercury, having had several near-death experiences, also saw the Black Flash. The eye can be considered as a living optical device.It is approximately spherical in shape, with its outer In this months Editors Choice feature, the editors note that certain perioperative decision making in thoracic surgery revolves around surgical dogma. Furthermore, characters with this type can be accurately described as being in either both or neither state of the dualities. WebAbout Our Coalition. This template will categorize articles that include it into the category "Flash Villains.". WebRome had begun expanding shortly after the founding of the Roman Republic in the 6th century BC, though it did not expand outside the Italian peninsula until the 3rd century BC. Variation of Alien Physiology and Transcendent Physiology. We own and operate 500 peer-reviewed clinical, medical, life sciences, engineering, and management journals and hosts 3000 scholarly conferences per year in the fields of clinical, medical, pharmaceutical, life sciences, business, engineering and technology. Naruto Uzumaki (Naruto) possesses a variety of different transformations/modes, such as. Put another way, the Maykr are not unlike how Tolkien's Elves would be if they had turned toward evil. [54], MS lesions are driven mainly by T-cells. The Slayer broke the Icon of Sin free from the Maykrs' control and subsequently breaking the seal blocking Urdak from Hell, allowing the demons to reject their pact with the Maykrs and invading Urdak. Variation of Archetype Empowerment. Omnipotence: As God, The Presence possesses infinite power. It is found in the gas state at room temperature. The Master Morpher (Power Rangers) allows Tommy Oliver to access his various Ranger powers. achieving normal concentrations) is therapeutic in MS by preventing BBB breakdown through inactivation of peroxynitrite. WebCosmic Entity Physiology/Cosmic Deity Physiology Cosmic Manipulation : Users can generate , shape , and manipulate cosmic energies to produce nearly any effect they desire. WebThe power to be an entity beyond all dimensionality. WebPassword requirements: 6 to 30 characters long; ASCII characters only (characters found on a standard US keyboard); must contain at least 4 different symbols; [72] Apart from that, activated T-Cells can cross a healthy BBB when they express adhesion proteins. Apart from white matter demyelination, the cortex and deep gray matter (GM) nuclei can be affected, together with diffuse injury of the NAWM. All for free. Gray VS Esdeath (Fairy Tail VS Akame ga Kill!) They are a hive-mind race, lead by the Khan Maykr. They first appeared in Doom Eternal. The most accepted sequence of events is first NAWM appearance, then the so-called pre-active lesions, with activated microglia, and finally the BBB breakdown, which enables the entry of T-cells to the CNS. There are three phases for how an unknown underlying condition may cause damage in MS: Multiple sclerosis differs from other idiopathic inflammatory demyelinating diseases in its confluent subpial cortical lesions. [17], Follicle-like aggregates in the meninges are formed only in secondary progressive MS.[18] and correlate with the degree of subpial cortical demyelination and brain atrophy, suggesting that they might contribute to cortical pathology in SPMS[18], These ectopic lymphoid follicles are composed mainly of EBV infected B-cells. The Maykrs' civilization inevitably came to an end due to the actions of the Doom Slayer during the Hell invasion of Earth orchestrated by the Khan Maykr to harvest the souls of the human race. Users' personality may change as well. Activation of macrophages and lymphocytes and their migration across the barrier may result in direct attacks on myelin sheaths within the central nervous system, leading to the characteristic demyelination event observed in MS.[59] After demyelination has occurred, the degraded myelin sheath components, such as myelin basic proteins and Myelin oligodendrocyte glycoproteins, are then used as identifying factors to facilitate further immune activity upon myelin sheaths. While normally covered entirely in white and gold armor plating, the Maykrs are actually flesh, despite them generally being referred to as 'ethereal beings' by other civilizations. Likewise, natural elements and even representations of them using Biomorphic Forms & Patterns create spaces that are comfortable [and] captivating 1. Beyond-Dimensional Existence Dimensionlessness Outerversal Outerversal Entity Physiology Outerversal Existence Xenodimensional [3] The scleroses that define the disease are the remainders of previous demyelinating lesions in the CNS white matter of a patient (encephalomyelitis) showing special characteristics, such as confluent instead of perivenous demyelination.[4]. Further activation of cytokines is also induced by macrophage and lymphocyte activity, promoting inflammatory activity as well continued activation of proteins such as matrix metalloproteinases, which have detrimental effect on BBB integrity. Their existence is fully transcendent of all dimensional levels on a conceptual or existential level, normally being portrayed as entirely external abstractions that lie outside of the applications of spatiotemporal dimensionality as a constant defined by physics on any level, even compared to infinite or uncountably infinite dimensions, usually by perceiving them as akin to fiction or something similarly insignificant. The Maykr species is believed to be ancient, and they generally consider themselves to be gods and far beyond the lives of other species, whom they refer to only as 'mortals.' Not to be confused with Personal Customization. That is to say, for any statement A about them they are in a state that can't be described as A is true, A is false, A is simultanously true and false or A is neither true nor false. The "Demons" (Witch Creek Road) are creature from outside of existence. For information regarding the procedure that needs to be exactly followed to register there, please click here. This brief review serves as a refresher on smooth muscle physiology for those educators who teach in medical and graduate courses of physiology. Increased expression of pro-inflammatory cell surface markers have been observed in NAWM and "initial" lesions, corresponding to a so-called loss of homeostatic microglial equilibrium. Triborg (Mortal Kombat X) is programmed with and can freely switch between the forms, powers, and move sets of four different Lin Kuei cyborgs: Cyrax, Sektor, Smoke Road Kamelot (D.Gray-man) due to possess the power of. The once holy realm fell into chaos as the Khan Maykr died at the hands of the Slayer. By the end of their lifespan, they inevitably suffer from some form of biological and mental degradation, at which point they undergo a process known as 'the Transfiguration' wherein they allow a voluntary death and resurrection somehow tied to the Father. The Maykr are in fact more like the Elves in J. R. R. Tolkien's legendarium -- a very long-lived, but still flawed, material species that undergoes a very slow "fading" like the Maykrs' Transfiguration, does have potential for evil under the right conditions, and Urdak is more like Valinor than the real Heaven. The original report[citation needed] suggests that there may be several types of MS with different immune causes, and that MS may be a family of several diseases. Current research in neuropathology, neuroimmunology, neurobiology, and neuroimaging, Editor/authors are masked to the peer review process and editorial decision-making of their own work and are not able to access this work in the online manuscript submission system. by Jo Chikwe, MD, FRCS, and Brian Mitzman, MD, FACS. [89] Some interactions between the Epstein-Barr virus and the HERVs could be the trigger of the MS microglia reactions. Upon the birth of the young girl, Grail was defended by her mother Follow Jamaican news online for free and stay informed on what's happening in the Caribbean Additionally, those professionals who are in need of an update on smooth muscle physiology may find this review to be useful. Django (Boktai) has two different modes: Sol Trance, in which he wields the powers of the sun and Dark Trance, in which he becomes a vampire wielding the power of darkness. Activated microglia in turn produces demyelination. Then, it was an "empire" (i.e., a great power) long before it had an emperor. They first appeared in Doom Eternal. These types of lesions are the most specific finding for MS, being exclusively present in MS patients, though currently they can only be detected at autopsy. Some clinical trials have shown that the inflammation produces both the relapses and the demyelination, and that neurodegeneration (axonal transection) is independent from inflammation, produces the accumulative disability, and advances even when inflammation and demyelination are delayed. Nomad's (Crysis) Nanosuit has four different modes: Armor, Strength, Speed, and Cloak. Jean Grey (Marvel Comics) has three different modes as Phoenix from being "Phoenix" then Dark Phoenix, her from as an evil and villainous Phoenix host and White Phoenix, her ultimate bond with the Phoenix Force entity. 61, pp. Master the subject, with dozens of easy-to-digest articles. With the aid of the DNA Splicers, Kyurem (Pokmon) can fuse with Zekrom to become Black Kyurem or Reshiram to become White Kyurem. Freely available at, Harnessing the clinical value of biomarkers in MS, International Journal of MS care, June 2012, Alireza Minagar and J Steven Alexander, Bloodbrain barrier disruption in multiple sclerosis. An unknown soluble factor (produced by CD8+ T-cells or CD20+ B-cells), creates a toxic environment that activates microglia. ", These differences are noticeable only in early lesions[38] and the heterogeneity was controversial for some time because some research groups thought that these four patterns could be a consequence of the age of the lesions. [91], Whatever the underlying primary condition is, it is expected to be a soluble factor in the CSF,[12] maybe an unknown cytokine or ceramide, or a combination of them. Their shape is influenced by their activity[49]. Several biomarkers for diagnosis, disease evolution and response to medication (current or expected) are under research. If as expected MS is an heterogeneous disease and the lesion development process would not be unique. "Do stressed oligodendrocytes trigger microglia activation in pre-active MS lesions?." Through his own will, he defined every variable physical law of the universe, stating everything happens because he makes it happen. Compared to normal endothelial cells, the cells lining the BBB are connected by occludin and claudin which form tight junctions in order to create a barrier to keep out larger molecules such as proteins. WebDimensional Entity Physiology; Doppelgnger Physiology; Draconic Abomination; Fanon:Dualis Physiology; E Earth-Bound Physiology; Eldritch Physiology; Elemental Energy Physiology; Elemental-Digital Physiology; Emotional Energy Physiology; Empowered Mortal Physiology; Energy Enhanced Physiology; 5 7 The Framingham Heart Study found that the incidence of heart failure was increased in both male and female diabetic patients when compared with age-matched individuals, and this association was It is also possible this is the Maykrs original appearance, but that countless of years of sustaining themselves on Argent Energy has corrupted their features. [39] Nevertheless, after some debate among research groups, the four patterns model is accepted and the exceptional case found by Prineas has been classified as NMO[40][41], For some investigation teams this means that MS is an immunopathogenetically heterogeneous disease. BBB disruption is the moment in which penetration of the barrier by lymphocytes occur and has been considered one of the early problems in MS lesions. [16] MS is active even during remission periods. The Maykrs betrayed the people ofArgent D'Nurand allied with the forces ofHellin exchange for a limitless supply of Argent Energy, the Maykrs would help the demons with the process of harvesting other races and harvesting their life essence, their souls, and further expand the dominion of Hell. This process, however, was compromised by the absence of the Father's essence, leaving the Maykrs fearful of losing their wisdom and faculties. And so they must obey a many-valued logic with at least 5 truth states, and not be in any of the 4 combinations of true and false mentioned earlier. Willow Rosenberg (Buffy the Vampire Slayer) alternating between. Type 2 (General Transduality): Characters that exist in a nondual state regarding all dual systems within the scope of an entire level of reality and qualitatively superior or immune to the effects caused within it. Referring to MS, the physiology refers to the different processes that lead to the development of the lesions and the pathology refers to the condition associated with the lesions. Microvessels in periplaque areas coexpressed HLA-DR and VCAM-1, some others HLA-DR and urokinase plasminogen activator receptor, and others HLA-DR and ICAM-1. Type 3 (Plurality): Characters that exist in a nondual state regarding all dual systems within the scope of an entire level of reality and qualitatively superior or immune to the effects caused within it. as doll form to be easily concealed and carried by an ally, while in this form, she retains her abilities and can still speak and move. A more detailed evidence of a correlation between the place and type of venous malformations imaged and the reported symptoms of multiple sclerosis in the same patients was published in 2010. [1], According to the Maykrs' legends, their progenitor was an alien entity known as the Father. [72] (Adhesion molecules could also play a role in inflammation[73]) In particular, one of these adhesion proteins involved is ALCAM (Activated Leukocyte Cell Adhesion Molecule, also called CD166), and is under study as therapeutic target. WebDimensional Travel: The Black Flash can easily travel to and from the Speed Force at will. The Maykrs society is a form of hive-mind, with individuals that are more-or-less independent but obliged to always follow the will of their leader - theKhan Maykr. Superpower Wiki is a FANDOM Anime Community. It is not known what causes MS. Several problems appear together with the white matter lesions, like cortical lesions and normal-appearing tissues. This process could only be done via the help ofthe Father's essence. Most Maykr buildings are also richly adorned with various details and embellishments, statues of themselves, golden symbols from their language and more. The journal presents original contributions as well as a complete international abstracts section and other special departments to provide the most current source of information and references in pediatric surgery.The journal is based on the need to improve the surgical care of infants and children, not only through advances in physiology, An Abnormal Periventricular Gradient in Magnetisation Transfer Ratio Occurs Early in Multiple Sclerosis. Multiple sclerosis is an inflammatory demyelinating disease of the CNS in which activated immune cells invade the central nervous system and cause inflammation, neurodegeneration, and tissue damage. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL, 2013. inflammatory demyelinating disease of the CNS, idiopathic inflammatory demyelinating diseases, chronic cerebro-spinal venous insufficiency, "Perivenous demyelination: association with clinically defined acute disseminated encephalomyelitis and comparison with pathologically confirmed multiple sclerosis", "Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis", "Alpha-B-Crystallin Induces an Immune-Regulatory and Antiviral Microglial Response in Preactive Multiple Sclerosis Lesions", "Identifying the Start of Multiple Sclerosis Injury: A Serial DTI Study", "A serial study of new MS lesions and the white matter from which they arise", "The immunopathology of multiple sclerosis: an overview", "MR Spectroscopy Indicates Diffuse Multiple Sclerosis Activity During Remission", "Novel mechanisms of chronic inflammation in secondary progressive multiple sclerosis", "Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain", "Defective cholesterol clearance limits remyelination in the aged central nervous system", "Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis", "Part 1B Pathology: Lecture 11 - The Complement System", "A quantitative analysis of oligodendrocytes in multiple sclerosis lesions - A study of 113 cases", "Humoral pattern II multiple sclerosis pathology not associated with neuromyelitis Optica IgG", "Some MS patients have "Dramatic" responses to Plasma Exchange", "Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis", "Anoctamin 2 identified as an autoimmune target in multiple sclerosis", "Histopathology and clinical course of MOG-antibody-associated encephalomyelitis", "Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions", "Sequencing the immunopathologic heterogeneity in multiple sclerosis", "Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion", "Lesion genesis in a subset of patients with multiple sclerosis: A role for innate immunity? Though originally a biopsy was required to classify the lesions of a patient, since 2012 it is possible to classify them by a blood test[20] looking for antibodies against 7 lipids, three of which are cholesterol derivatives[21] Cholesterol crystals are believed to both impair myelin repair and aggravate inflammation. 3 Quotations by or about Grail (Prime Earth), She was first mentioned, although unnamed, in. [70], Whether BBB dysfunction is the cause or the consequence of MS[71] is disputed, because activated T-Cells can cross a healthy BBB when they express adhesion proteins. WebEpidemiology of Diabetes MellitusRelated Heart Failure. In-game codex entries suggests they may have done this to multiple civilizations across the entire galaxy, which may include Earth during ancient times, for millions of years. Venous insufficiency: Some morphologically special medullar lesions (wedge-shaped) have also been linked to venous insufficiency. [62], Postmortem studies of the BBB, especially the vascular endothelium, show immunological abnormalities. These increase BBB T-cell permeability, specially in the case of MMP-9[60] and are supposedly related to the mechanism of action of interferons. WebThe human eye is a sensory organ, part of the sensory nervous system, that reacts to visible light and allows humans to use visual information for various purposes including seeing things, keeping balance, and maintaining circadian rhythm.. Damadian RV, Chu D. The possible role of cranio-cervical trauma and abnormal CSF hydrodynamics in the genesis of multiple sclerosis, 2011, Raymond V. Damadian and David Chu, The Possible Role of Cranio-Cervical Trauma and Abnormal CSF Hydrodynamics in the Genesis of Multiple Sclerosis. [77] Some molecular biochemical models for relapses have been proposed. Endothelium: Other theories point to a possible primary endothelial dysfunction. This great being is said to have either been "split" to form the Maykr race, or to have transferred his incalculable power into the vast structure known as Urdak which then birthed the Maykrs in perpetuity. Some areas that appear normal under normal MRI look abnormal under special MRI, like magnetisation transfer MTR-MRI. The Flash Vol 2 #138(June, 1998). First Appearance Visually, the Maykrs resemble humanoid beings with two arms each ending in three to five digits. The lower section of the Maykrs, however, is split into several tendrils or tentacles. Opposite to Mode Lock. Hans-Peter Hartung et al, Efficacy and Safety of Temelimab, an Antibody Antagonist of the Human Endogenous Retrovirus Type-W env Protein, in Participants with Relapsing Remitting Multiple Sclerosis: A Double-Blind, Randomised, Placebo-Controlled Phase 2b Clinical Trial, The Lancet 17 May 2019, Putnam, T.J. (1937) Evidence of vascular occlusion in multiple sclerosis. -Superpower Fanon(Omnipotence, Omni Transcendence, Gestalt Monotheistic Deity Physiology, Meta Miracle Manipulation Pages). The Black Flash appeared to the fourth Flash, Bart Allen, immediately before his death at the hands of the Rogues at the Getty Center.[1]. [127][128], In 2016 a similar association was reported for anti-Anoctamin-2[129]. Haemodynamic problems have been found in the blood flow of MS patients using Doppler, CSF flow: Other theories focus in the possible role of, This page was last edited on 2 December 2022, at 04:52. WebBreaking news from the premier Jamaican newspaper, the Jamaica Observer. In particular, some PPMS patients have been found to have a special genetic variant named rapidly progressive multiple sclerosis[47] which would behave differently from what here is explained. [63], The damaged white matter is known as "Normal-appearing white matter" (NAWM) and is where lesions appear. Currently antibodies to lipids and peptides in sera, detected by microarrays, can be used as markers of the pathological subtype given by brain biopsy. Opposite to Mode Lock. [12], Most MS findings take place inside the white matter, and lesions appear mainly in a periventricular distribution (clustered around the ventricles of the brain). WebBiology is the scientific study of life. The "Taiji" is the limitless potential and oneness before duality. Type 1 (Specific Transduality): Characters that exist in a nondual state regarding one specific dual system and qualitatively superior or immune to effects caused within it. [52], Some authors report active lesion formation before BBB breakdown;[53] others point to adipsin as a factor of the breakdown. [67] Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1alpha through Lyn kinase. -Superpower Fanon(Omnipotence, Omni Transcendence, Gestalt Monotheistic Deity Physiology, Meta Miracle Manipulation Pages). Sub-power of Mode Manipulation. WebResearchGate is a network dedicated to science and research. [81] The low level of uric acid found in people with MS is manifestedly causative rather than a tissue damage consequence in the white matter lesions,[82] but not in the grey matter lesions. Outerversal variation of Dimensional Entity Physiology. [57] This results in disruption of the BBB, causing an increase in barrier permeability due to the degradation of tight junctions which maintain barrier integrity. Thanks to the Rumble Ball, Tony Tony Chopper (One Piece) has developed a variety of different transformations, each with its own advantages and after training for 2 years, he only needs to eat one Rumble Ball to transform into his Monster Point form, having mastered it. Combination of Evolution and Super Form. Tommy Oliver (Power Rangers) possesses a new Morpher called the Master Morpher that allows him to access all his Ranger Powers. Transduality is not simply nonduality, but additionally requires something like qualitative superiority or immunity to attacks bound to the duality in question. Associations. In order to secure a supply of Argent Energy, the Maykrs has taken to invading other planets or dimensions to harvest the energy of other lifeforms. WebRome had begun expanding shortly after the founding of the Roman Republic in the 6th century BC, though it did not expand outside the Italian peninsula until the 3rd century BC. Dante (DmC: Devil May Cry) can switch between angelic and demonic modes, gaining different weapons and powers. Not to be confused with Personal Customization. WebFandom Apps Take your favorite fandoms with you and never miss a beat. What remained of the Father is his essence that resided in a temple-like building, the Luminarium, where Maykrs would go to seek answers.[1]. The underbanked represented 14% of U.S. households, or 18. In latter, an external factor produces BBB leaks, enters the CNS, and destroys myelin and axons. Retrieved October 11, 2018, "GDP-l-fucose synthase is a CD4+ T cellspecific autoantigen in DRB3*02:02 patients with multiple sclerosis", "pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis", "Human retrovirus pHEV-W envelope protein and the pathogenesis of multiple sclerosis", "Multiple sclerosis pathology: evolution of pathogenetic concepts", "7T MRI: New Vision of Microvascular Abnormalities in Multiple Sclerosis", "Normal-appearing White and Grey Matter Damage in Multiple Sclerosis. [78], Normally, gadolinium enhancement is used to show BBB disruption on MRIs. A duality refers to a logical duality for the purpose of this ability. Maykr technology is complex, sophisticated and generally very refined. 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